Rescue therapy was used in 7% of patients treated with JANUVIA 100 mg and 14% of patients treated with placebo. No adverse effect on fertility was observed at 125 mg/kg (approximately 12 times human exposure at the MRHD of 100 mg/day based on AUC comparisons). At higher doses, nondose-related increased resorptions in females were observed (approximately 25 and 100 times human exposure at the MRHD based on AUC comparison). Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications.
What are the serious side effects of Januvia
In combination with metformin and rosiglitazone, JANUVIA provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo with metformin and rosiglitazone (Table 12) at Week 18. At Week 54, mean reduction in A1C was -1.0% for patients treated with JANUVIA and -0.3% for patients treated with placebo in an analysis based on the intent-to-treat population. https://sober-house.net/faqs-what-are-fentanyl-test-strips/ Rescue therapy was used in 18% of patients treated with JANUVIA 100 mg and 40% of patients treated with placebo. There was no significant difference between JANUVIA and placebo in body weight change. Inform patients that severe and disabling joint pain may occur with this class of drugs. The time to onset of symptoms can range from one day to years.
Are you already on metformin but not at your A1C goal? Adding JANUVIA to metformin may help.
Whether or not you need to take insulin depends on the amount of sugar in your blood. Your doctor will look at your lab tests and treatment history to decide whether you need insulin with Januvia. You should take Januvia according to your doctor or healthcare professional’s instructions. Januvia stops the activity of a protein called dipeptidyl peptidase 4 (DPP-4). DPP-4 reduces the amount of two substances that decrease the amount of insulin in your body. These chemicals are called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
What foods should I eat or avoid for hypoglycemia?
Do not share Januvia with other people, even if they have the same condition as you. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Ask a pharmacist
Clinical studies looked at the effect of cinnamon on people with type 2 diabetes. These people took between 0.5 g and 6 g of cinnamon each day for 40 days to four months. In some studies, cinnamon was effective at improving blood sugar levels.
The recommended starting dose is 50 mg sitagliptin/500 mg metformin. Patients should take Janumet twice daily with meals, and dose increases should be gradual to minimize gastrointestinal side effects from metformin. Januvia may also come with more rare but serious side effects.
That said, you shouldn’t change your dose without talking with your doctor. In this case, your doctor may prescribe you 25 mg or 50 mg of the drug once per day. This is because the kidneys break down the drug in the body. And if your kidneys aren’t working correctly, you may get too much Januvia in your body with the alcohol withdrawal typical dosage. JANUVIA may have other side effects, including stomach upset and diarrhea, swelling of the hands or legs, when JANUVIA is used with metformin and rosiglitazone (Avandia). The most common side effects of JANUVIA include upper respiratory infection, stuffy or runny nose and sore throat, and headache.
For more information on the possible side effects of Januvia, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may bother you. The following lists contain some of the key side effects that may occur while taking Januvia. For many adults, the American Diabetes Association recommends an A1C goal of less than 7%. Some people might need a different individual A1C goal.
Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions. https://sober-home.org/does-ketamine-cause-cardiac-arrest/ Below is a list of medications that can interact with Januvia. This list doesn’t contain all drugs that may interact with Januvia.
In the 18-week study, 521 patients were randomized to placebo, JANUVIA 100 mg, or JANUVIA 200 mg, and in the 24-week study 741 patients were randomized to placebo, JANUVIA 100 mg, or JANUVIA 200 mg. Patients who failed to meet specific glycemic goals during the studies were treated with metformin rescue, added on to placebo or JANUVIA. Across clinical studies, the incidence of laboratory adverse reactions was similar in patients treated with JANUVIA 100 mg compared to patients treated with placebo. A small increase in white blood cell count (WBC) was observed due to an increase in neutrophils. Mean (SE) increases in serum creatinine were observed in patients treated with JANUVIA [0.12 mg/dL (0.04)] and in patients treated with placebo [0.07 mg/dL (0.07)]. The clinical significance of this added increase in serum creatinine relative to placebo is not known.
But according to a review of clinical studies, it’s not clear whether chromium is effective and safe for treating high blood sugar caused by type 2 diabetes. Different types of diabetes medications can help manage blood sugar levels in people with diabetes. Your doctor will recommend which drugs you’ll need to take for your blood sugar levels. Januvia acts quickly to block a certain protein in your body. But you might not notice a difference in your blood sugar levels until several months have passed.
- Januvia works to help keep your blood sugar levels from getting too high.
- Approximately 79% of sitagliptin is excreted unchanged in the urine with metabolism being a minor pathway of elimination.
- This can lead to a condition called hypoglycemia (low blood sugar).
- Tell your healthcare provider if you have any of these side effects that bother you.
- The pre-specified primary efficacy analyses included data from study 1 and pooled data from studies 2 and 3, regardless of glycemic rescue or treatment discontinuation.
- Advise patients of the characteristic symptoms of heart failure and to immediately report such symptoms.
This pain can spread to your back, and it may or may not cause you to vomit. If you notice these symptoms, tell your doctor right away. More studies are needed to confirm whether it’s effective and safe for people to take cinnamon for type 2 diabetes. There haven’t been clinical studies in humans to determine whether Januvia is safe to take during pregnancy.